In the human body growth hormone is produced by the pituitary gland. It exists at especially high levels during adolescence when it promotes the growth of tissues, protein deposition and the breakdown of subcutaneous fat stores. Upon maturation endogenous levels of GH decrease, but remain present in the body at a substantially lower level. In the body the actual structure of growth hormone is a sequence of 191 amino acids. Once scientists isolated this hormone, many became convinced it would exhibit exceptional therapeutic properties. It would be especially effective in cases of pituitary deficient dwarfism, the drug perhaps restoring much linear growth if administered during adolescence.
He 1980’s brought about the first prepared drugs containing Human Growth Hormone. The content was taken from a biological origin, the hormone being extracted from the pituitary glands of human corpses then prepared as a medical injection. This production method was short lived however, since it was linked to the spread of a rare and fatal brain disease. Today virtually all forms of HGH are synthetically manufactured. The recombinant DNA process is very intricate; using transformed e-coli bacterial or mouse cell lines to genetically produce the hormone structure. It is highly unlikely you will ever cross the old biologically active item on the black market (such as Grorm), as all such products should now be discontinued. Here in the United States two distinctly structured compounds are being manufactured for the pharmaceutical market. The item Humatrope by Eli Lilly Labs has the correct 191 amino acid sequence while Genentech’s Protropin has 192. This extra amino acid slightly increases the chance for developing an antibody reaction to the growth hormone. The 191 amino acid configuration is therefore considered more reliable, although the difference is not great. Protropin is still Anabolics 2002 considered an effective product and is prescribed regularly. Outside of the U.S., the vast majority of HGH in circulation will be the correct 191 amino acid sequence so this distinction is not a great a concern.