Finasteride that is a specific inhibitor of 5a-reductase. Proscar is the enzyme responsible for converting testosterone into DHT (dihydrotestosterone). Proscar can efficiently reduce the serum concentration of DHT, therefore Proscar minimizes the unwanted androgenic effects that result from its presence. Propecia is the same drug but the tablet contains only 115 of the Proscar dosage. Scientists have long believed that DHT was the main Finasteride culprit in many cases of male hair loss (along with genetic factors), so there was little doubt after the release of Proscar that Finasteride would eventually be used for this purpose.
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On the part of the reproductive system: rarely – impotence, decreased libido, decreased ejaculate volume, gynecomastia.
Allergic reactions: skin rash, angioedema.
There was no clinically significant interaction of finasteride with propranolol, digoxin , glyburide, warfarin, theophylline and antipyrin.
It seems that finasteride does not significantly affect the enzymatic system of cytochrome P450 and, accordingly, does not affect the pharmacokinetic indices of drugs metabolized by microsomal liver enzymes.
With simultaneous application of finasteride with ACE inhibitors, alpha-blockers, beta-blockers, calcium channel blockers , nitrates, diuretics, blockers of histamine H 2 receptor antagonists, inhibitors of HMG-KoA reductase inhibitors, NSAIDs, quinolones and benzodiazepines no clinically significant drug interactions.